Key Points In a recent study, researchers found that prebiotic supplements helped ease knee arthritis symptoms. So, should you head to your drugstore to purchase a prebiotic supplement to treat your pain? , board-certified clinical specialist in orthopedic physical therapy and owner of ActiveCare Physical TherapyWhy might prebiotic supplements relieve arthritis pain? People with knee arthritis aren’t the only ones who may benefit from taking a prebiotic supplement. “Other modalities like [ice or heat], laser, acupuncture, and massage are helpful for those with knee arthritis,” Wu points out.