LONGER screen time was associated with poorer dermatology-related quality of life among adolescents with skin disease. Validated questionnaires assessed dermatology-related and general quality of life, anxiety, self-esteem, body image, life satisfaction, and health behaviors. Quality of Life Tracks Psychosocial HealthGreater dermatology-related quality-of-life impairment was significantly associated with poorer overall quality of life, lower self-esteem, a more negative body image, and greater anxiety. The average Dermatology Life Quality Index score indicated that chronic skin disease had a small overall effect across the sample. Further longitudinal studies could clarify how chronic skin disease, digital media exposure, health values, and psychosocial well-being interact over time.