The Guardians (82-71) are coming off a 6-2 win in the series opener on Friday. Guardians right-hander Slade Cecconi (6-6, 4.39 ERA) will take on Twins right-hander Joe Ryan (13-8, 3.35) in the first matchup. He has no decisions and a 4.09 ERA in two games (one start) vs. the Guardians this year. In the nightcap, Guardians left-hander Logan Allen (7-11, 4.36 ERA) will go up against Twins right-hander Bailey Ober (5-8, 5.12). He is 0-2 with a 5.30 ERA in seven starts since then.