The M72 vaccine is currently on phase three trials in five countries, including South Africa. The Health Department is gearing up for the arrival of a breakthrough tuberculosis (TB) vaccine, a potential game‑changer that could help wipe out the epidemic as a public health threat by 2030. The department said the M72/ASOIE vaccine is currently in phase three trials in five countries, including South Africa. “A vaccine that prevents TB disease in adolescents and adults will be a game-changer for TB control and elimination, both globally and here in South Africa,” Mohale said. “This is arguably a major step toward a new TB vaccine – the first significant advance since BCG more than 100 years ago.”