Intimacy doesn’t have to wait until bedtime if that is when your energy is lowest. [3] Amifampridine (Firdapse) , a first-line therapy for LEMS, reaches its highest blood concentration relatively quickly, about 30 to 60 minutes after a dose. Keep track of when you usually feel strongest and when possible, try to plan intimacy within that window, says Galvez-Jimenez. You can pause, change positions, focus on touching or kissing, or let your partner take the lead while your muscles recover. [2] You can pause, change positions, focus on touching or kissing, or let your partner take the lead while your muscles recover.