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Amendment to 3,4-MDP-2-P Methyl Glycidic Acid, a List I Chemical
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Federal Register Documents published on or after 08/24/2025
3,4-MDP-2-P Methyl Glycidic Acid and Its Esters3,4-MDP-2-P methyl glycidic acid is used in the manufacture of the list I precursor chemical 3,4-MDP-2-P, the schedule I substance MDMA, and other “ecstasy”-like substances.
Since 2011, there have been 29 reports of the sodium and potassium salts of 3,4-MDP-2-P methyl glycidic acid, including over 16 metric tons of 3,4-MDP-2-P methyl glycidic acid salts reported in the Precursors Incident Communication System (PICS).
Since 2021, there have been 154 reports through PICS of the ethyl ester of 3,4-MDP-2-P methyl glycidic acid totaling more than 104 metric tons of the ethyl ester of 3,4-MDP-2-P methyl glycidic acid.
This proposed rule would not affect current handlers of 3,4-MDP-2-P methyl glycidic acid, including its salts, optical and geometric isomers, and salts of isomers, as they would already be registered to handle 3,4-MDP-2-P methyl glycidic acid.
* * * * * (a) * * * (35) 3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid) and its esters, not listed elsewhere in the CSA, its optical and geometric isomers, its salts, salts of its optical and geometric isomers, salts of its esters, not listed elsewhere in the CSA, and any combination thereof, whenever the existence of such is possible, including the following: 8525 ( printed page 48793) (i) Ethyl ester of 3,4-MDP-2-P methyl glycidic acid (ethyl 3-(benzo[d][1,3]dioxol-5-yl)-2-methyloxirane-2-carboxylate; 3,4-MDP-2-P ethyl glycidate; PMK ethyl glycidate) (ii) Propyl ester of 3,4-MDP-2-P methyl glycidic acid (propyl 3-(benzo[d][1,3]dioxol-5-yl)-2-methyloxirane-2-carboxylate; 3,4-MDP-2-P propyl glycidate; PMK propyl glycidate) (iii) Isopropyl ester of 3,4-MDP-2-P methyl glycidic acid (isopropyl 3-(benzo[d][1,3]dioxol-5-yl)-2-methyloxirane-2-carboxylate; 3,4-MDP-2-P isopropyl glycidate; PMK isopropyl glycidate) (iv) Butyl ester of 3,4-MDP-2-P methyl glycidic acid (butyl 3-(benzo[d][1,3]dioxol-5-yl)-2-methyloxirane-2-carboxylate; 3,4-MDP-2-P butyl glycidate; PMK butyl glycidate) (v) Isobutyl ester of 3,4-MDP-2-P methyl glycidic acid (isobutyl 3-(benzo[d][1,3]dioxol-5-yl)-2-methyloxirane-2-carboxylate; 3,4-MDP-2-P isobutyl glycidate; PMK isobutyl glycidate) (vi) sec-Butyl ester of 3,4-MDP-2-P methyl glycidic acid ( sec -butyl 3-(benzo[d][1,3]dioxol-5-yl)-2-methyloxirane-2-carboxylate; 3,4-MDP-2-P sec-butyl glycidate; PMK sec-butyl glycidate (vii) tert-Butyl ester of 3,4-MDP-2-P methyl glycidic acid ( tert -Butyl 3-(benzo[d][1,3]dioxol-5-yl)-2-methyloxirane-2-carboxylate; 3,4-MDP-2-P tert-butyl glycidate; PMK tert-butyl glycidate, as list I chemicals under the CSA.