The 12-page guidance, which was publicly released on Tuesday, stops federal assistance for domestic dangerous gain-of-function — or DGOF — research and certain international research of concern. President Donald Trump previously signed a May 2025 executive order on biological research security and safety that called, in part, for ending DGOF research. Although AI and other emerging technologies have the ability to enhance biological research, some experts have warned that the tools also have the theoretical capacity to develop new deadly pathogens. “The White House Office of Science and Technology Policy (OSTP) will convene an interagency group to monitor advancements at the intersection of biological sciences and artificial intelligence, including in silico life sciences research,” the guidance says. The policy also looks to create a clear delineation between research it defines as high-risk and other solely tech-based studies.