18F-FDG PET/CT has demonstrated significant diagnostic utility in the evaluation of several inflammatory and infectious diseases Domenico AlbanoFUO presents a significant diagnostic challenge because of its wide range of potential causes. “Although predominantly used in oncology, 18F-FDG PET/CT has demonstrated significant diagnostic utility in the evaluation of several inflammatory and infectious diseases. Researchers then evaluated the role that 18F-FDG PET/CT played in diagnosis and clinical management, as well as its association with clinical, epidemiologic, and biochemical parameters. 18F-FDG PET/CT scans had positive results for 549 patients and negative results for the remaining 380 patients. “In addition, the integration of clinical and biochemical parameters may help improve performance of 18F-FDG PET/CT, reducing the time to diagnosis and preventing unnecessary treatments and investigations.”