The new statement primarily evaluates caffeinated coffee and its possible relationship with high blood pressure, cholesterol, Type 2 diabetes, coronary heart disease, stroke, heart failure, atrial fibrillation, and other abnormal heart rhythms. That is approximately the amount in 3 to 5 8-ounce cups of regular black caffeinated coffee (without sugars, sweeteners, flavors, or added fillers). Short-term responses can include greater alertness and temporary increases in blood pressure, heart rate, and blood sugar. Specific Health Effects of CaffeineEffects on blood pressure : Caffeinated coffee may affect blood pressure differently depending on how much a person drinks. Effects on heart disease and stroke: Consuming 2-4 cups of caffeinated coffee per day was associated with a lower risk of heart disease, heart failure, and stroke.