The other five teams Mahomes is unbeaten against are on the Chiefs' 2026 schedule. Mahomes against the 49ersThe Chiefs and Mahomes will host the 49ers in Week 16 this season, two days after Christmas. Across those games, he has averaged 302 passing yards while throwing 10 touchdown passes and six interceptions. Mahomes against the FalconsThe week after hosting the Jets, Mahomes and the Chiefs will travel to Atlanta in mid-November. Mahomes has averaged 304.5 passing yards in his two games against Arizona.