The NCCIH has been researching natural products since 1999, establishing key principles, though the need for more insights remains. The article warns that ‘natural’ does not always equate to safe, particularly when products interact with medicationsMany people see natural products – botanicals, dietary supplements, and probiotics – as a way to shore up their health or manage health concerns. Building on what we knowNCCIH has been supporting research on natural products since 1999. Natural products taken in combination with prescription medications – like St. John’s wort and depression medications – can endanger health. Deeper insights on interconnections in healthResearch on natural products is illuminating the complex systems and connections of human health.