Creating a 3D map of enhancer networks in prostate cancer could lead to targeted therapies

Using advanced 3D genome mapping technology to study prostate cancer cells, researchers have discovered a new feature of gene control networks that could help fight cancer. The findings could help with the development of targeted cancer therapies. Using 201 datasets from both prostate tumor samples and healthy prostate tissue, her team identified 3216 key enhancers specific to prostate cancer. They found that in prostate cancer cells, enhancers formed an interconnected 3D network that did not exist in normal prostate cells. Targeting central enhancers for future therapiesThe discovery that some enhancers serve as key control points could inform future cancer therapies.