I’ve also made repeated reference to my own explanatory account, the Mutual Vulnerability Theory of Laughter, and suggested it’s the most comprehensive theory available. In this post, I want to set aside the micro lens I typically employ and offer up a bird's-eye view of laughter and humor theory. Exactly how might one determine whether any theory is suitably comprehensive to truly explain why we produce this rather odd vocalization? For neuroscientists, including those who investigate atypical laughter, understanding where in the brain the stimulus for laughter originates is paramount. A fully comprehensive laughter theory must be able to stretch, twist, and bend as needed, but not break from its central tenets.