And there’s one combination of these ingredients in particular has quietly stood the test of time: Matrixyl 3000. So what can Matrixyl 3000 help with specifically? Unlike newer skincare ingredients, Matrixyl 3000 has been around long enough to accumulate meaningful research, though dermatologists warn that the evidence isn’t perfect. How to Use Matrixyl 3000Fortunately, incorporating Matrixyl 3000 into your routine is pretty straightforward. “Matrixyl 3000 can be used in the morning, at night or twice daily depending on the instructions for the individual formula,” she adds.