LIFESTYLE modification significantly reduced intrapancreatic fat, reinforcing the role of non-pharmacological interventions in improving metabolic health and supporting strategies to prevent type 2 diabetes and pancreatic disease. While lifestyle interventions are already established as an effective approach for reducing liver fat, evidence for their impact on intrapancreatic fat has been less clear. Diet and Exercise Delivered Consistent BenefitsResearchers analysed 23 interventional studies evaluating lifestyle modification programmes in which intrapancreatic fat was measured using magnetic resonance-based imaging techniques. Across the pooled analysis, lifestyle interventions resulted in a significant reduction in intrapancreatic fat and an absolute reduction in magnetic resonance imaging measured intrapancreatic fat. Effects of lifestyle modification on intrapancreatic fat deposition: a systematic review and meta-analysis.