Knowing what symptoms to watch for in the days after a tick bite can mean the difference between early treatment and serious complications. Warmth radiating from the bite site, pus formation, or red streaking away from the wound all suggest bacterial infection requiring antibiotics. It begins at the bite site after a delay of three to 30 days, with most appearing around day seven. Symptoms typically develop between three and 30 days after an infected tick bite. The Bottom LineMonitoring tick bite symptoms in the days after a bite enables early treatment before complications develop.