The FDA approved Tylenol with Naproxen on July 24, the first nonprescription fixed-dose combination pairing acetaminophen with naproxen sodium. According to the agency, each tablet contains 325 mg of acetaminophen and 110 mg of naproxen sodium. The FDA lists the tablet as 325 mg of acetaminophen and 110 mg of naproxen sodium. Kenvue describes a dose as 650 mg of acetaminophen and 220 mg of naproxen sodium. Those most at risk are people who add a second acetaminophen or NSAID product without checking labels, and older adults.