According to Sam, as much as 30% of your collagen is lost in just five years in your 50s. These are the skin’s ultimate back-up – when UV and pollution get to your skin, antioxidants are the final line of defence. Again, use vitamin C on the neck and chest, and look out for ceramides to keep the skin plump and hydrated.” THE TREATMENT TO TRY: “Hormonal changes can cause the skin to become drier and thinner. Mesotherapy – injecting the skin with a powerful cocktail of vitamins, enzymes and antioxidants – is great for intense hydration, resulting in a renewed healthy glow.”