If everyone picked a favorite Seinfeld quote, they might each say something different. There's one quote from George around halfway through the series that I think most would point to as being particularly significant, and it's also just plain funny. George Changes Everything in the 'Seinfeld' Episode 'The Opposite'NBCIf George weren't such a self-deprecating character, Seinfeld would be a very different (and much less hilarious) TV show. Thankfully for us, he rarely has any confidence — except in one memorable episode that I think has the best Seinfeld quote. I like George's usual humble self... and I also like the glimpse we see of how different his life could be.