Researchers have confirmed New York State’s first case of Bourbon virus, a rare and potentially severe infection carried by lone star ticks. Bourbon virus was first identified in Bourbon County, Kansas, in 2014. Bourbon virus may be missed because most clinicians have never encountered it and cannot order a standard commercial test to confirm the diagnosis. “For these reasons, the Bourbon virus is likely more prevalent than we think in our region, and other cases are likely not being diagnosed.” Two people had neutralizing antibodies against the Bourbon virus, showing that their immune systems had encountered it.