A major crash involving two vehicles near the I-49 and I-10 interchange in Lafayette sent four people to the hospital Wednesday afternoon, including two drivers who suffered critical injuries. Four people transported to Lafayette hospitalPolice said the drivers of both vehicles suffered critical injuries in the crash. Drivers asked to avoid I-49 and I-10 crash areaThe crash occurred on a heavily traveled portion of Lafayette's interstate system where northbound I-49 traffic connects with westbound I-10. Motorists traveling through the I-49 and I-10 interchange should be prepared for possible delays and use an alternate route if available. Investigators have not yet determined why the first vehicle left the roadway before traveling up the embankment.