If you are worried that you may have an imbalance in your gut microbiome, talk to your doctor. Several strategies can rebuild a healthy gut microbiome. If there’s an imbalance in the gut microbiome, one way to improve gut homeostasis is to increase your intake of dietary fiber. If there’s an imbalance in the gut microbiome, one way to improve gut homeostasis is to increase your intake of dietary fiber. If you have any questions about how the medication you take might affect your gut microbiome, talk to your doctor.