Destroy a brain tumor with laser while keeping the most delicate nervous structures of the brain under control in real time. This is the approach applied at the IRCCS Neuromed in Pozzilli, where laser thermoablation (LITT, Laser Interstitial Thermal Therapy) has been integrated with advanced anatomical-functional study and monitoring techniques of the brain. The procedure involves the introduction of an optical fiber with a diameter of less than 2 millimeters into the brain. The element that characterized the procedure is the integration of the laser with the most modern brain imaging technologies. “LITT is a therapeutic option applicable in selected cases of primary or metastatic brain tumors located in particularly deep or critical areas.