Glioblastoma is the most common and most aggressive brain cancer in adults and currently has no cure. Using different mouse models and performing precise neurosurgery to remove the growing glioblastoma tumours from their brains, the team tracked fluorescently labelled, liposomal nanoparticles injected into the blood stream during the time-windows identified. The particles homed in on the resection margin with remarkable precision while other brain regions with an intact barrier showed almost no uptake. Lipid nanoparticle medicines are based on tiny lipid-based nanoscale carriers that can ferry different cancer drugs (such as chemotherapies, radiotherapies, mRNA therapies) directly to tumours so the medicine targets the cancer cells alone. Across different mouse models, a single injection of this liposomal drug was able to suppress recurrence and control the disease with little toxicity.the first half of your story here.