ADVERTISEMENTHere are some of the best road trip destinations in Southern Africa. Garden Route: South Africa’s iconic road trip destinationStretching between Mossel Bay and Storms River, the Garden Route is one of Africa’s most famous driving routes. According to The South African Guide, the Garden Route follows South Africa’s southern coast between Mossel Bay and Storms River, making it one of the country’s most iconic road trips. Blyde River Canyon, South AfricaThe Panorama Route is one of South Africa’s finest scenic drives. Maloti Mountains, LesothoLesotho’s mountain roads provide one of Southern Africa’s most rewarding driving experiences.