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Cheap, efficient, programmable DNA synthesis method could transform biocomputing
['Beatrice Bowlby']
News Archives - BioTechniques
A new DNA synthesis method that relies on temperature rather than the endless replacement of reagents and molecular building blocks could prove a vital innovation in the field of biocomputing.
A collaborative South Korean research effort led by Yeongjae Choi of the Korea Advanced Institute of Science and Technology (Daejeon, South Korea) has developed a cheap, efficient method of DNA synthesis that could be used for innovative DNA coding and nanotechnology solutions.
Typical DNA synthesis methods involve a constant cycling of reagents as bases or DNA fragments are swapped in and out during synthesis, making workflows long, expensive and complex.
Each DNA hairpin essentially acts as a template on which the novel strand can be synthesized.
This enables a synthesis approach that can be ‘programmed’ by adding a specific selection of DNA hairpins into the reaction mixture along with a primer.