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A small mutation, a big impact: New findings on cardiomyopathies
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Pressemitteilungen - idw - Informationsdienst Wissenschaft
Instanz: TeilenTeilen:A small mutation, a big impact: New findings on cardiomyopathiesRobert Emmerich Presse- und ÖffentlichkeitsarbeitJulius-Maximilians-Universität Würzburg29.07.2026 10:00Researchers from Würzburg und Heidelberg have unravelled why minor changes in the heart protein RBM20 can lead to different inherited heart diseases.
Cardiomyopathies are a group of mostly hereditary, rare heart diseases in which the structure of the heart muscle tissue is impaired.
In the other family, the condition is left ventricular non-compaction cardiomyopathy (LVNC), in which the heart tissue is riddled with sponge-like holes.
Artificial heart tissue and gene scissors usedTo understand the processes described, the team recreated the patients’ condition in the laboratory.
Three models were used in the investigations: individual heart cells, spherical organoids and small artificial heart muscle tissues.