These so-called Nuclear Lifecycle Innovation Campuses are an ambitious project by the Trump Administration to store and repurpose spent nuclear fuel, support advanced reactor deployment, expand domestic manufacturing, and potentially co-host data centers. Campuses in the five Republican-governed states would be designed to support activities across the full nuclear fuel lifecycle, including fuel fabrication, enrichment, reprocessing used nuclear fuel, and final disposition of used nuclear fuel. The United States currently has no permanent disposal facility for spent nuclear fuel or other highly radioactive waste. As of 2025, more than 95,000 metric tons of spent nuclear fuel were stored across 79 sites in over 30 states. Reprocessed fuel could be used in advanced nuclear reactors, which could be developed at the new Nuclear Lifecycle Innovation Campuses.