However, the study authors recommended further research to better understand the safety of GLP-1 use during pregnancy. However, the study authors recommended further research to better understand the safety of GLP-1 use during pregnancy. “With the growing number of patients on GLP-1 receptor agonists, early pregnancy exposure is something we are encountering more often in routine care.” Many women worry that GLP-1 medications might harm their fertility or future pregnancies, but the evidence so far does not support that concern. Research in patients with obesity has found that GLP-1 medications can improve fertility, increase spontaneous pregnancy rates, and help regulate menstrual cycles.