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Healthy pregnancies and newborns are possible after CAR T cell therapy
['Aimee Cunningham', 'Tom Metcalfe', 'Lily Burton', 'Cassie Martin', 'Meghan Rosen', 'Katarina Zimmer', 'Melissa Hobson', 'Katherine Kornei', 'Emily Conover', 'Fechi Inyama']
Science News
After CAR T cell therapy, seven women had healthy newborns and five more were experiencing regular pregnancies as of late May, researchers report July 29 in the New England Journal of Medicine.
CAR T cell therapy was pioneered as a treatment for cancer, but there are very few reports of pregnancy in those circumstances.
The treatment involves engineering certain immune cells, called T cells, into destroyers of other immune cells, called B cells, which are attacking the body.
All had undergone CAR T cell therapy for autoimmune diseases, largely for lupus, and all were in remission.
In further testing of five of the newborns, the researchers found the expected immune cell allotments.