People classified in what researchers call Tübingen type 2 diabetes risk cluster 5 lost roughly 8 percent of their body weight and kept it off for years. The confirmed finding is that in this analysis, one high-risk prediabetes subgroup showed worsening glucose and the steepest decline in insulin secretion despite sustained weight loss of about 8 percent. People in Tübingen type 2 diabetes risk cluster 5 had worsening blood glucose, the steepest decline in insulin secretion among the clusters, and continued high diabetes risk despite sustained weight loss of about 8 percent. Six subtypes of prediabetes were identified in 2021 that differ in diabetes risk and complication patterns. Clusters 1, 2, and 4 are lower risk; clusters 3, 5, and 6 are higher.