OverviewCan blueberries and grapes help protect your heart? A new review published in Nutrients found that blueberries, grapes, and the natural compounds they contain may help improve several markers linked to heart health. These compounds have antioxidant and anti-inflammatory properties that may help protect the heart. Some studies also found that grape products improved cholesterol levels and blood vessel health, especially in people with high cholesterol or metabolic problems. Polyphenols and Cardiovascular Health: Emerging Relevance for Blueberries, Grapes, and Red-Fleshed Table Grapes.