Whether similar benefits extend to older adults has remained uncertain, particularly because weight loss in this age group may increase the risk of frailty. Key findings include:The intervention group achieved significantly greater weight loss than the usual care group, with an average weight reduction of 9.7% compared with 3.1%. Despite the greater weight loss, AF symptom severity did not differ significantly between the two groups. The researchers conclude that moderate lifestyle-based weight loss alone is unlikely to be an effective treatment strategy for persistent AF in this population. Weight Loss in Older Patients With Persistent Atrial Fibrillation: The LOSE-AF Randomized Clinical Trial.