Non-energy-based aesthetic procedures, comprising botulinum toxin injections, hyaluronic acid fillers, chemical peels, microneedling, and microdermabrasion, have emerged as cornerstone minimally invasive interventions in contemporary dermo-cosmetology. [3]Non-Energy-Based Aesthetic Procedures: Disrupting Skin Barrier & Need for Periprocedural CareChemical peels, microneedling, and microdermabrasion universally disrupt the skin barrier through controlled injury mechanisms, triggering transient trans-epidermal water loss (TEWL) and an inflammatory cascade. [7]Key Takeaway✔ Non-energy procedures disrupt the skin barrier, triggering TEWL and an inflammatory cascade; disruption severity determines peri-procedural care intensity required. ✔ Experts recommend comprehensive periprocedural regimens with gentle cleansers, moisturizers, antioxidants, and SPF 50+ to reduce inflammation and PIH risk. Abbreviations: CoQ10, coenzyme Q10; HA, hyaluronic acid; PIH, post-inflammatory hyperpigmentation; SPF, sun protection factor; TEWL, transepidermal water loss.