A Growing Global ChallengeHeart failure (HF) remains a major cause of morbidity, hospitalization, and mortality worldwide. Medication non-adherence is a well-established determinant of adverse clinical outcomes, contributing to recurrent hospitalizations, disease progression, and increased mortality. Across these studies, medication non-adherence was greater than 50%, underscoring its substantial clinical burden. Financial and Family Support MatterSocial support emerged as a major determinant of medication adherence, often outweighing patient- and disease-related factors. The researchers concluded that identifying and addressing factors associated with medication non-adherence may improve self-care, treatment adherence, and quality of life in patients with heart failure.