Understanding the main causes of chronic liver disease Digital Edition: Understanding the main causes of chronic liver disease How fat build up in the liver, hepatitis infection and alcohol use disorder cause chronic liver disease. AbstractThe first article in this series on the liver discussed the function and structure of the normal, healthy liver. This second article focuses on the three most important causes of chronic liver disease: accumulation of excess fat in the liver, hepatitis infection and alcohol use disorder. Citation: Pratt J, Nigam Y (2026) Understanding the main causes and progression of chronic liver disease. To continue reading:Subscribe to get unlimited access To access this content, you’ll need a subscription to Nursing Times.