Simtriyo, the first ADHD medication in its class, is a norepinephrine, dopamine, and serotonin reuptake inhibitor. It might be a better choice for some patients with ADHD, compared with commonly prescribed ADHD medications like the stimulant drug Adderall (amphetamine and dextroamphetamine), according to doctors. Clinical Trials Found Simtriyo to Be Safe and EffectiveClinical trials of Simtriyo evaluated the impact of the drug on children, teens, and adults. Simtriyo Side Effects Are Similar to Other ADHD Medications[3] [4] Potential Simitriyo side effects that emerged in clinical trials include the following:Decreased appetiteNauseaHeadacheRashMost side effects were mild or moderate. Some patients don’t respond well to the existing battery of ADHD medications, and Simtriyo could simply provide another option.