Because of this, he says, “We recommend that patients with high blood pressure not use any decongestants.” He also recommends that even those with normal blood pressure try other medications, like antihistamines, before taking decongestants. (One exception is decongestants sold as a nasal spray, such as Afrin, which have less effect on blood pressure, says Dr. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, also increase blood pressure. While the ideal blood pressure is 120/80 millimeters of mercury (mmHg) or less, above 130/80 mmHg is considered high blood pressure and indicates that you should talk to your doctor.