Published in the journal Life, the review integrates emerging evidence from sleep science, vascular biology and nutritional neuroscience to explore the relationship between sleep quality, the brain’s glymphatic system and long-term neurovascular function. “The findings suggest that tocotrienols may help support several physiological processes associated with sleep inefficiency and healthy brain aging, including oxidative balance, vascular function and neuroinflammatory regulation,” she said. According to the review, sleep fragmentation may be associated with reduced efficiency of glymphatic activity and is linked to oxidative stress, inflammation and changes in neurovascular function. “Taken together, the bioavailability, antioxidant and anti-inflammatory actions, and endothelial-protective properties of tocotrienols converge to support a multilevel neurovascular protective profile,” the report said. Moreover, direct evidence linking supplementation to improvements in several specific markers of glymphatic function and brain waste clearance is currently lacking.