Researchers in China and Malaysia analyzed how the probiotic affected gene expression and suggested that “inflammatory, immune, neuroendocrine, and motility-related host-response pathways may be involved”. The strain L. plantarum Probio87 is isolated from breast milk and has shown gastrointestinal resilience and immune-modulatory effects in previous studies. Study detailsThe double-blind randomized controlled trial involved 104 adult participants with functional constipation. They consumed Lactiplantibacillus plantarum Probio87 or placebo for 8 weeks, followed by a 4-week post-intervention follow-up. Nutr., https://doi.org/10.3389/fnut.2026.1876944 “Lactiplantibacillus plantarum Probio87 supplementation improves functional constipation and is associated with peripheral gene-expression responses related to inflammation and the gut–brain axis: a randomized, double-blind, placebo-controlled trial.”