This edition of the DefenseTech Brief covers the week of April 21-27, 2025, a period marked by significant developments across multiple defense technology domains. Other notable events included major defense spending announcements, hypersonic program contracts, and space domain activities. Concurrently, Congressional Republicans proposed $27 billion initial funding for the ambitious “Golden Dome” homeland missile defense initiative, expanding US policy scope significantly beyond previous rogue-state focus. Mastering new domains (seabed, C-UAS) requires balancing technological advancement with managing proliferation and counter-capability risks. European defense collaboration shows promise in specific areas (Ukraine support via CV-90) but struggles at the strategic level (MGCS).