VIENNA (AP) — Iran's supreme leader on Tuesday rejected direct negotiations with the United States over his country's nuclear program, likely slamming the door shut on a last-ditch effort to halt the reimposition of United Nations sanctions on Tehran. Earlier this month, the U.N. nuclear watchdog and Iran signed an agreement mediated by Egypt to pave the way for resuming cooperation, including on ways of relaunching inspections of Iran’s nuclear facilities. That followed Israel’s 12-day war with Iran in June, during which Israel and the U.S. bombed Iranian nuclear sites. ___Gambrell reported from Dubai, United Arab Emirates and Amiri reported from the United Nations. Associated Press writer Nasser Karimi in Tehran, Iran, contributed to this report.