Outcomes included opioid abuse diagnoses, opioid prescribing, systemic complications, and prosthetic failures at 90 days and 5 years. The key findings of the study:• After matching, 90-day cohorts included 106,516 TKA patients and 46,227 THA patients per group; 5-year cohorts included 44,251 TKA and 16,019 THA patients per group. The authors concluded – “Perioperative antidepressant use is independently associated with increased postoperative opioid abuse and higher complication rates after TKA and THA. These findings support preoperative psychiatric screening, medication review, multimodal pain strategies, and closer monitoring to mitigate opioid-related harm in vulnerable arthroplasty patients.” For further details on the article refer to:Perioperative Antidepressant Use Increases the Risk of Opioid Abuse After Total Joint Arthroplasty Alireza Mirahmadi et al JBJS Open Access 2026:e26.00057.