With the Mega Millions jackpot climbing to an estimated $743 million for tonight's drawing, plenty of New Yorkers will be stopping for a ticket on their way home from work. The research analyzed every Powerball and Mega Millions drawing on record to see which numbers have appeared more often than expected over time. The Luckiest Mega Millions NumbersThe study also ranked Mega Millions numbers using the same method. On the opposite end of the spectrum, 51 ranked as the coldest Mega Millions number, appearing roughly 24% less often than expected. If you're planning to play for the estimated $743 million Mega Millions jackpot, remember that every drawing is completely random.