Yes, “post-coital dysphoria” is a real thing. And, unlike most things you see on the internet or hear on podcasts, there might be something to the link between testosterone and post-coital dysphoria. The issue, Dr. Houman says, is that lower testosterone levels can cause problems with mood and emotional regulation that can intensify post-coital dysphoria. So if you’re concerned about post-coital dysphoria, consulting with a urologist is the best course of action. Testosterone and post-coital dysphoriaYes, low testosterone levels can cause or worsen post-coital dysphoria, Dr. Houman says.