For good reason, too—scientists have spent decades researching creatine and found that active people who consistently take creatine supplements can enhance their strength and add muscle. If you're taking creatine, or if you're thinking about starting it, you'll want to know when is best to take it. Because the best time to take creatine supplements is every day. For certain people, post-workout creatine may provide some kind of edge: “The benefit of taking creatine post-workout is that muscle cells have a greater affinity for uptake of creatine after exercise,” says Iafelice. If you’re taking creatine, take it regularly, and don’t worry too much about when you take it.