Science is reshaping beauty — from the surface of the skin to the depths of the mind. Beginning with neuroscience, Unilever researchers explain how the predictive brain constructs rather than merely observes product benefits. In response, the authors designed fragranced formulas to manipulate this early processing step by the predictive brain. And Yvon, et al., present niacinamide as a dual-function ingredient to not only impart well-known skin benefits, but also provide antimicrobial product protection. As science pushes beauty deeper into the brain, skin barrier health and beyond, this issue maps where we’re headed next: more intelligent, integrated and human-centered personal care.