The second day of the IFSCC 2025 Congress was dedicated to holistic sciences, exploring the interconnected factors that define the health and beauty of skin and hair. He examined how modern hygiene practices and cosmetic ingredients can harm this delicate ecosystem and explored pathways to restore and sustain a healthy skin microbiome. Her work introduced the first multidimensional composite aging clock, comprising:Facial age,Phenotypic age,Transcriptomic age,Proteomic age,Metabolic age,Lipidomic age,Hormonal age,Immune age,Organ age andComposite biological age. Session Deep Dive: Microbiome and Well-AgingThroughout the day, parallel sessions will focus on two critical areas of holistic science: the microbiome and well-aging/longevity. In addition, the development of a bio-emulsion from a novel skin microbiome strain was presented.