Dental deep cleaning treats periodontal disease by removing plaque and hardened calculus from tooth roots below the gumline. Dental deep cleaning can cost $185 to $444 per quadrant, with full-mouth treatment reaching $740 to $1,776 before separate services. How Much Does Dental Deep Cleaning Cost? Published pricing material identifies tooth count, location, provider, dental plan, X-rays, and anesthesia as items that can change the total. Patients comparing this work with a routine dental cleaning should compare procedure codes, not labels.