Reigning champions Medeama SC will launch the defence of their 2026/27 Ghana Premier League crown with a tough away trip to Dreams FC, following the release of the new season's fixtures by the Football Association. The Mauve and Yellow enter the campaign on the back of a memorable title-winning season and will be determined to retain the Premier League crown. However, their quest for back-to-back league triumphs promises to be anything but straightforward, with a tricky fixture schedule awaiting the Tarkwa-based club from the opening weekend. Medeama's rivalry with fellow Western Region clubs will once again take centre stage during the campaign. The champions travel to FC Samartex 1996 on Matchday Seven in one of the season's most eagerly anticipated Western derbies before hosting Bibiani Gold Stars in another blockbuster fixture on Matchday 15.